About
Associate Professor Wei-Qiang Leow is currently a senior consultant pathologist at the Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital. He graduated from the Faculty of Medicine, National University of Singapore in 2006 and did his postgraduate training in Histopathology with the then Histopathology and Cytology Sections, Department of Pathology, Singapore General Hospital. He was awarded the fellowships from the Royal College of Pathologists of Australasia and Academy of Medicine Singapore in 2015. His interests are in hepatopancreatobiliary and gastrointestinal pathology.
In 2016, he was awarded the SingHealth Health Manpower Development Plan to pursue advanced diagnostic training and research in hepatopancreatobiliary pathology and liver cancers at the Mount Sinai Liver Cancer Program at the Tisch Cancer Institute, under the tutelage of Professors Swan N. Thung and Josep M. Llovet respectively. The Tisch Cancer Institute at Mount Sinai Hospital, New York, is the only National Cancer Institute designated Cancer Center in the United States with a dedicated liver cancer program. He has strong research interests in non-alcoholic fatty liver disease, hepatocellular carcinoma, cholangiocarcinoma, and colorectal carcinoma.
He has co-authored over 50 peer reviewed articles, and has co-written the textbook titled “Atlas of Hepatocellular Carcinoma Pathology”. He is an ad-hoc reviewer for Histopathology, Clinical Cancer Research, Molecular Cancer Research and other medical journals. He is also enthusiastic about teaching at the undergraduate and postgraduate levels, holding the concurrent appointments of Programme Director, SingHealth Pathology Residency Program and Director of Medical Student Education, SingHealth Pathology Academic Clinical Programme. In addition, he holds clinical associate professorships at Duke-NUS Medical School and School of Biological Sciences, Nanyang Technological University.
In 2016, he was awarded the SingHealth Health Manpower Development Plan to pursue advanced diagnostic training and research in hepatopancreatobiliary pathology and liver cancers at the Mount Sinai Liver Cancer Program at the Tisch Cancer Institute, under the tutelage of Professors Swan N. Thung and Josep M. Llovet respectively. The Tisch Cancer Institute at Mount Sinai Hospital, New York, is the only National Cancer Institute designated Cancer Center in the United States with a dedicated liver cancer program. He has strong research interests in non-alcoholic fatty liver disease, hepatocellular carcinoma, cholangiocarcinoma, and colorectal carcinoma.
He has co-authored over 50 peer reviewed articles, and has co-written the textbook titled “Atlas of Hepatocellular Carcinoma Pathology”. He is an ad-hoc reviewer for Histopathology, Clinical Cancer Research, Molecular Cancer Research and other medical journals. He is also enthusiastic about teaching at the undergraduate and postgraduate levels, holding the concurrent appointments of Programme Director, SingHealth Pathology Residency Program and Director of Medical Student Education, SingHealth Pathology Academic Clinical Programme. In addition, he holds clinical associate professorships at Duke-NUS Medical School and School of Biological Sciences, Nanyang Technological University.
Expertise
Researches
Powered by Google Scholar| TITLE | CITED BY | YEAR |
|---|---|---|
|
Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma
R Montal, D Sia, C Montironi, WQ Leow, R Esteban-Fabró, R Pinyol, ...
Journal of hepatology 73 (2), 315-327
|
238 | 2020 |
|
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
I Joanito, P Wirapati, N Zhao, Z Nawaz, G Yeo, F Lee, CLP Eng, ...
Nature genetics 54 (7), 963-975
|
215 | 2022 |
|
Trunk mutational events present minimal intra-and inter-tumoral heterogeneity in hepatocellular carcinoma
S Torrecilla, D Sia, AN Harrington, Z Zhang, L Cabellos, H Cornella, ...
Journal of hepatology 67 (6), 1222-1231
|
172 | 2017 |
|
Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification
C Montironi, F Castet, PK Haber, R Pinyol, M Torres-Martin, L Torrens, ...
Gut 72 (1), 129-140
|
170 | 2023 |
|
Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis
R Pinyol, S Torrecilla, H Wang, C Montironi, M Piqué-Gili, M Torres-Martin, ...
Journal of hepatology 75 (4), 865-878
|
167 | 2021 |
|
Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery
SB Ng, C Chua, M Ng, A Gan, PSY Poon, M Teo, C Fu, WQ Leow, KH Lim, ...
Scientific reports 7 (1), 40737
|
135 | 2017 |
|
Complexity of ballooned hepatocyte feature recognition: defining a training atlas for artificial intelligence-based imaging in NAFLD
EM Brunt, AD Clouston, Z Goodman, C Guy, DE Kleiner, C Lackner, ...
Journal of hepatology 76 (5), 1030-1041
|
124 | 2022 |
|
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
PHD Nguyen, S Ma, CZJ Phua, NA Kaya, HLH Lai, CJ Lim, JQ Lim, ...
Nature communications 12 (1), 227
|
122 | 2021 |
|
qFIBS: an automated technique for quantitative evaluation of fibrosis, inflammation, ballooning, and steatosis in patients with nonalcoholic steatohepatitis
F Liu, GBB Goh, D Tiniakos, A Wee, WQ Leow, JM Zhao, HY Rao, ...
Hepatology 71 (6), 1953-1966
|
119 | 2020 |
|
Hypoxia‐driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC
S Suthen, CJ Lim, PHD Nguyen, CA Dutertre, HLH Lai, M Wasser, ...
Hepatology 76 (5), 1329-1344
|
118 | 2022 |
|
A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
C Ho, Z Zhao, XF Chen, J Sauer, SA Saraf, R Jialdasani, K Taghipour, ...
Scientific reports 12 (1), 2222
|
110 | 2022 |
|
Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma
HHM Ng, RY Lee, S Goh, ISY Tay, X Lim, B Lee, V Chew, H Li, B Tan, ...
Journal for immunotherapy of cancer 8 (2)
|
100 | 2020 |
|
Expression of CD38 on macrophages predicts improved prognosis in hepatocellular carcinoma
JH Lam, HHM Ng, CJ Lim, XN Sim, F Malavasi, H Li, JJH Loh, K Sabai, ...
Frontiers in immunology 10, 2093
|
64 | 2019 |
|
Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease
PE Chang, GBB Goh, WQ Leow, L Shen, KH Lim, CK Tan
PLoS One 13 (6), e0199166
|
48 | 2018 |
|
Multiregion ultra‐deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer
Y Suzuki, SB Ng, C Chua, WQ Leow, J Chng, SY Liu, K Ramnarayanan, ...
Molecular oncology 11 (2), 124-139
|
48 | 2017 |
|
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma
PHD Nguyen, M Wasser, CT Tan, CJ Lim, HLH Lai, JJW Seow, ...
Nature communications 13 (1), 1441
|
44 | 2022 |
|
Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine
LC Phua, S Goh, DWM Tai, WQ Leow, SMF Alkaff, CY Chan, JH Kam, ...
Cancer Chemotherapy and Pharmacology 81, 277-289
|
36 | 2018 |
|
Impact of fatty liver on long-term outcomes in chronic hepatitis B: a systematic review and matched analysis of individual patient data meta-analysis
YJ Wong, VH Nguyen, HI Yang, J Li, MH Le, WJ Wu, NX Han, KY Fong, ...
Clinical and Molecular Hepatology 29 (3), 705
|
33 | 2023 |
|
Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study
W Zhai, H Lai, NA Kaya, J Chen, H Yang, B Lu, JQ Lim, S Ma, SC Chew, ...
National science review 9 (3), nwab192
|
32 | 2022 |
|
Non-alcoholic fatty liver disease: the pathologist’s perspective
WQ Leow, AWH Chan, PGL Mendoza, R Lo, K Yap, H Kim
Clinical and Molecular Hepatology 29 (Suppl), S302
|
29 | 2022 |